Modeling Drug Release

Milani Fard, Maryam; Milani Fard, Amir Mohammad

doi:10.22034/EJST.2022.1.2

Document Type : Review Article

Authors

¹ Graduate of Nursing, School of Nursing and Medical Emergency, Alborz University of Medical Sciences, Researcher of Baqiyatallah Hospital Research Center, Tehran, Iran

² Researcher at the Anesthesia and Pain, Molecular and Cell Biology Research Center, Faculty of Medicine Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran

https://doi.org/10.22034/EJST.2022.1.2

Abstract

Due to the diversity of polymers as well as their complex behavior, research in this field is still widely developed. Because biodegradable polymers become decomposed in the human body after decomposition, they are more commonly used because surgery is not required to remove these polymers from the body after the drug is released. Understanding the mechanism, modeling and studies of drug release from homopolymers, copolymers and mixtures of this family of polyesters is the focus of this research. In this research, the release of drug from homo and biodegradable copolymer in pure form with drug and finally the mixture of the two with drug has been investigated to determine the differences. In the proposed model, the equations that represent the degradation of the polymer are used to be able to predict the degradation of the polymer. The drug used is paclitaxel, which is a very important drug for chemotherapy. Since this drug is administered every 3 weeks for 3 hours, it is necessary to use controlled systems. Therefore, the purpose of this study is to achieve a predictable model for controlled release of paclitaxel, so that this model responds to the release of paclitaxel at any time.

Graphical Abstract

Keywords

Main Subjects

Clinical Medicine

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Eurasian Journal of Science and Technology

Modeling Drug Release

References

References

Volume 2, Issue 1
January 2022
Pages 14-33

Modeling Drug Release

References

References

Volume 2, Issue 1January 2022Pages 14-33

Volume 2, Issue 1
January 2022
Pages 14-33