Document Type : Original Research Article
Authors
1 Graduate of nursing, School of nursing and medical emergency, Alborz University of Medical ‎Sciences, Researcher of Baqiyatallah Hospital Research Center,‎ Tehran, Iran.
2 Researcher at the Anesthesia and Pain &Molecular and cell Biology Research cente, Faculty of Medicine Department of Anatomy, Iran university of Medical Sciences, Tehran, Iran.
Abstract
Due to the diversity of polymers as well as their complex behavior, research in this field is still widely developed. Because biodegradable polymers become decomposed in the human body after decomposition, they are more commonly used because surgery is not required to remove these polymers from the body after the drug is released. Understanding the mechanism, modeling and studies of drug release from homopolymers, copolymers and mixtures of this family of polyesters is the focus of this research. In this research, the release of drug from homo and biodegradable copolymer in pure form with drug and finally the mixture of the two with drug has been investigated to determine the differences. In the proposed model, the equations that represent the degradation of the polymer are used to be able to predict the degradation of the polymer. The drug used is paclitaxel, which is a very important drug for chemotherapy. Since this drug is administered every 3 weeks for 3 hours, it is necessary to use controlled systems. Therefore, the purpose of this study is to achieve a predictable model for controlled release of paclitaxel, so that this model responds to the release of paclitaxel at any time.
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