Clinical Medicine
Mohammad Sadegh Sanie Jahromi; Reza Sahraeai; Shahram Shafa; Mojtaba Ghaedi; Mahbobeh Ranjbar; Hasan Zabetian
Abstract
Introduction: Pain and anxiety after surgery is an unpleasant experience that occurs following various stimuli and humans react to it. This process causes physiological disorders in all body systems. Therefore, the purpose of this study is to compare the effect of oral melatonin and gabapentin ...
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Introduction: Pain and anxiety after surgery is an unpleasant experience that occurs following various stimuli and humans react to it. This process causes physiological disorders in all body systems. Therefore, the purpose of this study is to compare the effect of oral melatonin and gabapentin on pain and anxiety in patients undergoing upper extremity orthopedic surgery under general anesthesia.Methods: In this double-blind randomized clinical trial study, 90 patients with anesthesia class 1 and 2 underwent upper limb orthopedic surgery with general anesthesia. Patients were divided into 3 groups, gabapentin, melatonin, and placebo. VAS scale was used to measure patients' pain. Patients' hemodynamic symptoms were further investigated. Data analysis was done using descriptive and inferential statistical tests at a significance level of P<0.05.Results: 90 patients underwent upper limb orthopedic surgery under general anesthesia. There was no significant difference between the three groups of gabapentin, melatonin, and placebo in the incidence of pain at different times (P<0.05). Trends in mean diastolic blood pressure was not significant (P=0.612). Trends in the average heart rate from the time before entering the operating room to recovery and its exit was not significant (P<0.05).Conclusion: The results of the present study showed that both gabapentin and melatonin drugs have no effect on postoperative pain in patients undergoing upper limb orthopedic surgery, and it may be better to use other drugs or in combination with other sedative drugs.
Clinical Medicine
Mansour Rezaei; Ramin Azhough
Abstract
Introduction: Diosmin is effective in inhibiting the inflammatory response pathways and improving the acute and chronic symptoms of hemorrhoids. Very few studies have been conducted in this field, and the effectiveness of this drug in different studies has not been presented in a single study so that ...
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Introduction: Diosmin is effective in inhibiting the inflammatory response pathways and improving the acute and chronic symptoms of hemorrhoids. Very few studies have been conducted in this field, and the effectiveness of this drug in different studies has not been presented in a single study so that it can be used or not used based on its results. Therefore, the present study aims to investigate the effectiveness of Diosmin on pain after hemorrhoidectomy in the form of a systematic review of clinical trial studies.Methods: The present study was a systematic review that was designed and conducted based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement. The search was done in SID, Magiran, Embase, PubMed, Cochrane Library, Scopus, and Web of Science databases by following the entry and exit criteria and the keywords such as pain, hemoroide, hemorrhoidectomy, Diosmin, surgery, and post-operative.Results: 824 patients participated in these 4 randomized clinical trial studies (with a high quality). The instrument used to assess pain intensity in all studies was the Visual Analogic Scale. Diosmin tablets were prescribed in two forms: 500 mg (in three studies) and 300 mg (in one study) after hemorrhoidectomy. In three studies, Diosmin tablets led to a reduction in pain intensity after hemorrhoidectomy, and in one study, no significant difference was seen.Conclusion: The results of our study indicated that the use of 500 mg Diosmin oral tablets can lead to a reduction in pain intensity after hemorrhoidectomy. Due to the lower number of studies, the results of this study should be used with caution.
Clinical Medicine
Mojtaba Ghaedi; Elham Javidmehr; Navid Kalani; Hasan Zabetian
Abstract
Background: To relieve the pain caused by propofol injection, a wide range of medicinal and non-pharmacological methods have been investigated. The present study was conducted with the aim of comparing two drugs, ephedrine and dexamethasone, on the pain caused by propofol injection in patients undergoing ...
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Background: To relieve the pain caused by propofol injection, a wide range of medicinal and non-pharmacological methods have been investigated. The present study was conducted with the aim of comparing two drugs, ephedrine and dexamethasone, on the pain caused by propofol injection in patients undergoing elective surgery.Methods: This double-blind randomized clinical trial study was conducted on 60 patients who were candidates for elective surgery referred to Peymaniyeh Hospital in Jahrom City. Patients were divided into two groups A: dexamethasone with a dose of 8 mg/kg and group B: ephedrine with a dose of 5 mg using a table of random numbers. Dexamethasone and ephedrine were injected within 5 seconds, and after 30 seconds, propofol 1% in the amount of 3 ml (equivalent to 30 mg) was injected into the corresponding vein at a speed of 0.5 ml per second. After the injection, the patient was clearly asked about pain or discomfort at the injection site, and the answer was yes or no, and if there was pain, its severity was recorded in the questionnaire based on verbal descriptions. The data was analyzed using SPSS Software (version 21) and using descriptive (frequency, number, standard deviation, and mean) and inferential (Chi-square test) statistics. P<0.05 was considered as significant.Findings: 60 patients included in the study were divided into two groups of 30 dexamethasone and ephedrine. There was no statistically significant difference between both groups in terms of demographic characteristics (age, gender, and weight) and they were the same. Comparing the pain made by propofol injection in dexamethasone and ephedrine groups, using the Chi-square test, showed that the frequency of pain in the ephedrine group (33.3%) was not significant compared with dexamethasone group (40%) (P=0.23).Conclusion: Based on the results of the present study, although more people in the ephedrine group were pain free, the amount of pain in the ephedrine and dexamethasone groups was not statistically significant.
