h-index: 7     i10-index: 6

Document Type : Mini-Review

Authors

1 Department of Chemical Sciences, Federal University Wukari, Taraba State, Nigeria

2 Department of BioTechnology Federal University of Technology Owerri, Nigeria

10.48309/ejst.2024.449519.1134

Abstract

An invaluable method for assessing the surface morphology of a wide range of materials and samples, including those used in medical applications, is scanning electron microscopy (SEM). Scanning Electron Microscopy (SEM) has long been an indispensable tool in materials science and nanotechnology, providing unparalleled insights into the microstructure and surface morphology of various materials. Recent advancements have extended the utility of SEM beyond traditional fields, including its promising applications in medicine and biomedical research. By leveraging the high-resolution imaging capabilities of SEM, researchers can delve deeper into the intricate structures of biological specimens, complexities of cellular architecture, tissue organization, and disease pathology. SEM provides more information on biocompatibility, surface interactions, and structural integrity of medical implants and devices, paving the way for enhanced diagnostic and therapeutic strategies. SEM has long been used to characterize the surface topography of cells and tissues. SEM has been utilized in Cell Surface Imaging, Drug delivery system, Tissue Microstructure, gastrointestinal, and cardiology to advance understanding of disease early stages. SEM can produce high-resolution pictures of inanimate and biological particles, allowing for a thorough examination of a range of medical applications.

Keywords

Main Subjects

OPEN ACCESS

©2024 The author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit: http://creativecommons.org/licenses/by/4.0/

PUBLISHER NOTE

Sami Publishing Company remains neutral concerning jurisdictional claims in published maps and institutional affiliations.

CURRENT PUBLISHER

Sami Publishing Company

[1] Boyde A., Maconnachie E., Freon 113 freeze‐drying for scanning electron microscopy. Scanning, 1979, 2:164 [Crossref], [Google Scholar], [Publisher]‎
[2] Goldstein J.I., Newbury D.E., Michael J.R., Ritchie N.W., Scott J.H.J., Joy D.C., Scanning electron microscopy and X-ray microanalysis,  Springer, 2017 [Google Scholar], [Publisher]‎
[3] Wyffels J.T., Principles and techniques of electron microscopy: biological applications, by MA Hayat. Microscopy and Microanalysis, 2001, 7:66 [Google Scholar], [Publisher]‎
[4] Alberts B., Johnson A., Lewis J., Raff M., Roberts K., Walter P., Molecular Biology of the Cell. New York: Garland Science, Taylor and Francis Group, 2015, 4:973 [Crossref], [Google Scholar], [Publisher]‎
[5] Pawley J. B., Handbook of biological techniques (3rd ed.). San Diego: Elsevier. 2007 [Publisher]‎
[6] Hayat M.A., Principles of electron microscopy (7th ed.). Boca Raton: CRC Press. 2016 [Publisher]‎
[7] Humenansky J., Using SEM for medical applications. Medical Device and Diagnostic Industry, 2003, 25:108 [Publisher]‎
[8] Avula A., Galor A., Blackwelder P., Carballosa-Gautam M., Hackam A.S., Jeng B., Kumar N., Application of scanning electron microscopy with energy-dispersive X-ray spectroscopy for analyzing ocular surface particles on Schirmer strips, Cornea, 2017, 36: 752 [Crossref], [Google Scholar], [Publisher]‎
[9] Hyams T.C., Killingsworth M.C., Scanning electron microscopy as a new tool for diagnostics in pathology, Microscopy and Microanalysis, 2019, 25:1118 [Crossref], [Google Scholar], [Publisher]‎
[10] Kluzik A., Tomczak H., Nowicki M., Grześkowiak M., Kusza K., Scanning electron microscope examination as an alternative to classical microbiology in the diagnostics of catheter-related sepsis?, International Journal of Environmental Research and Public Health, 2023, 20:5028 [Crossref], [Google Scholar], [Publisher]‎
[11] Brahim Belhaouari D., Fontanini A., Baudoin J.P., Haddad G., Le Bideau M., Bou Khalil J.Y., Raoult D., La Scola B., The strengths of scanning electron microscopy in deciphering SARS-CoV-2 infectious cycle, Frontiers in Microbiology, 2020,11:2014 [Crossref], [Google Scholar], [Publisher]‎
[12] Möller L., Holland G., Laue M., Diagnostic electron microscopy of viruses with low-voltage electron microscopes. Journal of Histochemistry & Cytochemistry, 2020, 68:389 [Crossref], [Google Scholar], [Publisher]‎
[13] Klang V., Matsko N.B., Electron microscopy of pharmaceutical systems. In Advances in Imaging and Electron Physics Elsevier, 2014,  181:125 [Crossref], [Google Scholar], [Publisher]‎
[14] House K.L., Pan L., O'Carroll D.M., Xu S., Applications of scanning electron microscopy and focused ion beam milling in dental research, European Journal of Oral Sciences, 2022, 130:12853 [Crossref], [Google Scholar], [Publisher]‎
[15] Khan M.S.I., Oh S.W., Kim Y.J., Power of scanning electron microscopy and energy dispersive X-ray analysis in rapid microbial detection and identification at the single cell level. Scientific reports, 2020, 10:2368 [Crossref], [Google Scholar], [Publisher]‎
[16] Dusevich V., Melander J.R., Eick J.D., 13 SEM in dental research, Scanning Electron Microscopy for the Life Sciences, 2012, 211 [Crossref], [Google Scholar], [Publisher]‎
[17] Samuel H.S., Etim E.E., Shinggu J.P., Bako B., Machine learning of Rotational spectra analysis in interstellar medium,  Communication in Physical Sciences, 2023, 10:172 [Google Scholar], [Publisher]‎
[18] Risnes S., Saeed M., Sehic A., Scanning electron microscopy (SEM) methods for dental enamel. Odontogenesis,  Methods and Protocols, 2019, 293 [Google Scholar], [Publisher]‎
[19] Nikara S., Ahmadi E., Nia A.A., Effects of different preparation techniques on the microstructural features of biological materials for scanning electron microscopy, Journal of Agriculture and Food Research, 2020, 2:100036 [Crossref], [Google Scholar], [Publisher]‎
[20] Sharma V., Bhardwaj A., Scanning electron microscopy (SEM) in food quality evaluation. In Evaluation technologies for food quality Woodhead Publishing, 2019, 743 [Crossref], [Google Scholar], [Publisher]‎
[21] Klang V., Valenta C., Matsko N.B., Electron microscopy of pharmaceutical systems,  Micron, 2013, 44:45 [Crossref], [Google Scholar], [Publisher]‎
[22] Samuel H.S., Ekpan F.M., Revolutionizing drugs administration: Techniques in drug delivery and development, International Journal of Biochemistry & Physiology, 2023,  8:237 [Crossref], [Google Scholar], [Publisher]‎
[23] Nanou A., Crespo  M., Flohr P., De Bono J.S. Terstappen L.W., Scanning electron microscopy of circulating tumor cells and tumor-derived extracellular vesicles. Cancers2018, 10:416 [Crossref], [Google Scholar], [Publisher]‎