TY - JOUR ID - 132074 TI - Modeling Drug Release JO - Eurasian Journal of Science and Technology JA - EJST LA - en SN - AU - Milani Fard, Maryam AU - Milani Fard, Amir Mohammad AD - Graduate of Nursing, School of Nursing and Medical Emergency, Alborz University of Medical Sciences, Researcher of Baqiyatallah Hospital Research Center, Tehran, Iran AD - Researcher at the Anesthesia and Pain, Molecular and Cell Biology Research Center, Faculty of Medicine Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran Y1 - 2022 PY - 2022 VL - 2 IS - 1 SP - 14 EP - 33 KW - Drug release KW - degradable polymer KW - model KW - Control System KW - Paclitaxel DO - 10.22034/EJST.2022.1.2 N2 - Due to the diversity of polymers as well as their complex behavior, research in this field is still widely developed. Because biodegradable polymers become decomposed in the human body after decomposition, they are more commonly used because surgery is not required to remove these polymers from the body after the drug is released. Understanding the mechanism, modeling and studies of drug release from homopolymers, copolymers and mixtures of this family of polyesters is the focus of this research. In this research, the release of drug from homo and biodegradable copolymer in pure form with drug and finally the mixture of the two with drug has been investigated to determine the differences. In the proposed model, the equations that represent the degradation of the polymer are used to be able to predict the degradation of the polymer. The drug used is paclitaxel, which is a very important drug for chemotherapy. Since this drug is administered every 3 weeks for 3 hours, it is necessary to use controlled systems. Therefore, the purpose of this study is to achieve a predictable model for controlled release of paclitaxel, so that this model responds to the release of paclitaxel at any time. UR - https://ejst.samipubco.com/article_132074.html L1 - https://ejst.samipubco.com/article_132074_867e1ee6490f2f4a4caa9cb64852a4a1.pdf ER -